Mutant and wild-type isocitrate dehydrogenase 1 share enhancing mechanisms involving distinct tyrosine kinase cascades in cancer

Isocitrate dehydrogenase 1 (IDH1) is important for reductive carboxylation in cancer cells, and IDH1 R132H mutant plays a pathogenic role in cancers including acute myeloid leukemia (AML). However, the regulatory mechanisms modulating IDH1 mutant and/or wild-type (WT) function remain unknown. Here w...

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Publicado en:Cancer Discov
Autores principales: Chen, Dong, Xia, Siyuan, Wang, Mei, Lin, Ruiting, Li, Yuancheng, Mao, Hui, Aguiar, Mike, Famulare, Christopher A., Shih, Alan H., Brennan, Cameron W., Gao, Xue, Pan, Yaozhu, Liu, Shuangping, Fan, Jun, Jin, Lingtao, Song, Lina, Zhou, An, Mukherjee, Joydeep, Pieper, Russell O., Mishra, Ashutosh, Peng, Junmin, Arellano, Martha, Blum, William G., Lonial, Sagar, Boggon, Titus J., Levine, Ross L., Chen, Jing
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548588/
https://ncbi.nlm.nih.gov/pubmed/30862724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1040
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