Mechanism for IL-15-driven B-CLL cycling: Roles for AKT and STAT5 in modulating Cyclin D2 and DNA damage response proteins (1)

Clonal expansion of B-cell chronic lymphocytic leukemia (B-CLL) occurs within lymphoid tissue pseudofollicles. IL-15, a stromal cell-associated cytokine found within spleens and lymph nodes of B-CLL patients, significantly boosts in vitro cycling of blood-derived B-CLL cells following CpG DNA primin...

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Bibliografiska uppgifter
I publikationen:J Immunol
Huvudupphovsmän: Gupta, Rashmi, Li, Wentian, Yan, Xiao J, Barrientos, Jacqueline, Kolitz, Jonathan E., Allen, Steven L., Rai, Kanti, Chiorazzi, Nicholas, Mongini, Patricia K. A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548510/
https://ncbi.nlm.nih.gov/pubmed/30988120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801142
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