Binding of CLL Subset 4 B Cell Receptor Immunoglobulins to Viable Human Memory B Lymphocytes Requires a Distinctive IGKV Somatic Mutation

Amino acid replacement mutations in certain chronic lymphocytic leukemia (CLL) stereotyped B cell receptor (BCR) immunoglobulins (IGs) at defined positions within antigen-binding sites strongly imply antigen selection. Prime examples of this are CLL subset 4 BCR IGs using IGHV4-34/IGHD5-18/IGHJ6 and...

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Detalhes bibliográficos
Publicado no:Mol Med
Main Authors: Catera, Rosa, Liu, Yun, Gao, Chao, Yan, Xiao-Jie, Magli, Amanda, Allen, Steven L, Kolitz, Jonathan E, Rai, Kanti R, Chu, Charles C, Feizi, Ten, Stamatopoulos, Kostas, Chiorazzi, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: Feinstein Institute for Medical Research 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364113/
https://ncbi.nlm.nih.gov/pubmed/28097289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2017.00003
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