Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation

Enhancer of zeste homolog 2 (EZH2)-mediated trimethylation of histone 3 lysine 27 (H3K27Me3) is critical for immune regulation. However, evidence is lacking to address the effect of EZH2 enzyme’s activity on intestinal immune responses during inflammatory bowel disease (IBD). Here we report that sup...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Zhou, Jie, Huang, Shuo, Wang, Zhongyu, Huang, Jiani, Xu, Liang, Tang, Xuefeng, Wan, Yisong Y., Li, Qi-jing, Symonds, Alistair L. J., Long, Haixia, Zhu, Bo
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547712/
https://ncbi.nlm.nih.gov/pubmed/31160593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10176-2
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