Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation

Enhancer of zeste homolog 2 (EZH2)-mediated trimethylation of histone 3 lysine 27 (H3K27Me3) is critical for immune regulation. However, evidence is lacking to address the effect of EZH2 enzyme’s activity on intestinal immune responses during inflammatory bowel disease (IBD). Here we report that sup...

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Pubblicato in:Nat Commun
Autori principali: Zhou, Jie, Huang, Shuo, Wang, Zhongyu, Huang, Jiani, Xu, Liang, Tang, Xuefeng, Wan, Yisong Y., Li, Qi-jing, Symonds, Alistair L. J., Long, Haixia, Zhu, Bo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547712/
https://ncbi.nlm.nih.gov/pubmed/31160593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10176-2
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