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Smyd2 conformational changes in response to p53 binding: role of the C‐terminal domain

Smyd2 lysine methyltransferase regulates monomethylation of histone and nonhistone lysine residues using S‐adenosylmethionine cofactor as the methyl donor. The nonhistone interactors include several tumorigenic targets, including p53. Understanding this interaction would allow the structural princip...

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Foilsithe in:Mol Oncol
Main Authors: Chandramouli, Balasubramanian, Melino, Gerry, Chillemi, Giovanni
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547616/
https://ncbi.nlm.nih.gov/pubmed/31069954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12502
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