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SPLUNC1 Degradation by the Cystic Fibrosis Mucosal Environment Drives Airway Surface Liquid Dehydration

Cystic fibrosis (CF) is a multi-organ disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene that leads to diminished transepithelial anion transport. CF lungs are characterised by airway surface liquid (ASL) dehydration, chronic infection/inflammation and neutrophili...

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Detalhes bibliográficos
Publicado no:Eur Respir J
Main Authors: Webster, Megan J., Reidel, Boris, Tan, Chong D., Alexis, Neil E., Donaldson, Scott H., Kesimer, Mehmet, Ribeiro, Carla M.P., Tarran, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547379/
https://ncbi.nlm.nih.gov/pubmed/30190268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/13993003.00668-2018
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