SPLUNC1 Degradation by the Cystic Fibrosis Mucosal Environment Drives Airway Surface Liquid Dehydration

Cystic fibrosis (CF) is a multi-organ disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene that leads to diminished transepithelial anion transport. CF lungs are characterised by airway surface liquid (ASL) dehydration, chronic infection/inflammation and neutrophili...

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Vydáno v:Eur Respir J
Hlavní autoři: Webster, Megan J., Reidel, Boris, Tan, Chong D., Alexis, Neil E., Donaldson, Scott H., Kesimer, Mehmet, Ribeiro, Carla M.P., Tarran, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547379/
https://ncbi.nlm.nih.gov/pubmed/30190268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/13993003.00668-2018
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