Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial

IMPORTANCE: Patients with locally advanced pancreatic cancer have historically poor outcomes. Evaluation of a total neoadjuvant approach is warranted. OBJECTIVE: To evaluate the margin-negative (R0) resection rate of neoadjuvant FOLFIRINOX (fluorouracil, leucovorin, oxaliplatin, and irinotecan) and...

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Detalles Bibliográficos
Publicado en:JAMA Oncol
Main Authors: Murphy, Janet E., Wo, Jennifer Y., Ryan, David P., Clark, Jeffrey W., Jiang, Wenqing, Yeap, Beow Y., Drapek, Lorraine C., Ly, Leilana, Baglini, Christian V., Blaszkowsky, Lawrence S., Ferrone, Cristina R., Parikh, Aparna R., Weekes, Colin D., Nipp, Ryan D., Kwak, Eunice L., Allen, Jill N., Corcoran, Ryan B., Ting, David T., Faris, Jason E., Zhu, Andrew X., Goyal, Lipika, Berger, David L., Qadan, Motaz, Lillemoe, Keith D., Talele, Nilesh, Jain, Rakesh K., DeLaney, Thomas F., Duda, Dan G., Boucher, Yves, Fernández-Del Castillo, Carlos, Hong, Theodore S.
Formato: Artigo
Idioma:Inglês
Publicado: American Medical Association 2019
Assuntos:
Original Investigation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547247/
https://ncbi.nlm.nih.gov/pubmed/31145418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2019.0892
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