Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial

IMPORTANCE: Patients with locally advanced pancreatic cancer have historically poor outcomes. Evaluation of a total neoadjuvant approach is warranted. OBJECTIVE: To evaluate the margin-negative (R0) resection rate of neoadjuvant FOLFIRINOX (fluorouracil, leucovorin, oxaliplatin, and irinotecan) and...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JAMA Oncol
Prif Awduron: Murphy, Janet E., Wo, Jennifer Y., Ryan, David P., Clark, Jeffrey W., Jiang, Wenqing, Yeap, Beow Y., Drapek, Lorraine C., Ly, Leilana, Baglini, Christian V., Blaszkowsky, Lawrence S., Ferrone, Cristina R., Parikh, Aparna R., Weekes, Colin D., Nipp, Ryan D., Kwak, Eunice L., Allen, Jill N., Corcoran, Ryan B., Ting, David T., Faris, Jason E., Zhu, Andrew X., Goyal, Lipika, Berger, David L., Qadan, Motaz, Lillemoe, Keith D., Talele, Nilesh, Jain, Rakesh K., DeLaney, Thomas F., Duda, Dan G., Boucher, Yves, Fernández-Del Castillo, Carlos, Hong, Theodore S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Medical Association 2019
Pynciau:
Original Investigation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547247/
https://ncbi.nlm.nih.gov/pubmed/31145418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2019.0892
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