Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial

IMPORTANCE: Patients with locally advanced pancreatic cancer have historically poor outcomes. Evaluation of a total neoadjuvant approach is warranted. OBJECTIVE: To evaluate the margin-negative (R0) resection rate of neoadjuvant FOLFIRINOX (fluorouracil, leucovorin, oxaliplatin, and irinotecan) and...

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Dades bibliogràfiques
Publicat a:JAMA Oncol
Autors principals: Murphy, Janet E., Wo, Jennifer Y., Ryan, David P., Clark, Jeffrey W., Jiang, Wenqing, Yeap, Beow Y., Drapek, Lorraine C., Ly, Leilana, Baglini, Christian V., Blaszkowsky, Lawrence S., Ferrone, Cristina R., Parikh, Aparna R., Weekes, Colin D., Nipp, Ryan D., Kwak, Eunice L., Allen, Jill N., Corcoran, Ryan B., Ting, David T., Faris, Jason E., Zhu, Andrew X., Goyal, Lipika, Berger, David L., Qadan, Motaz, Lillemoe, Keith D., Talele, Nilesh, Jain, Rakesh K., DeLaney, Thomas F., Duda, Dan G., Boucher, Yves, Fernández-Del Castillo, Carlos, Hong, Theodore S.
Format: Artigo
Idioma:Inglês
Publicat: American Medical Association 2019
Matèries:
Original Investigation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547247/
https://ncbi.nlm.nih.gov/pubmed/31145418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2019.0892
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