Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial

IMPORTANCE: Patients with locally advanced pancreatic cancer have historically poor outcomes. Evaluation of a total neoadjuvant approach is warranted. OBJECTIVE: To evaluate the margin-negative (R0) resection rate of neoadjuvant FOLFIRINOX (fluorouracil, leucovorin, oxaliplatin, and irinotecan) and...

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Detalhes bibliográficos
Publicado no:JAMA Oncol
Main Authors: Murphy, Janet E., Wo, Jennifer Y., Ryan, David P., Clark, Jeffrey W., Jiang, Wenqing, Yeap, Beow Y., Drapek, Lorraine C., Ly, Leilana, Baglini, Christian V., Blaszkowsky, Lawrence S., Ferrone, Cristina R., Parikh, Aparna R., Weekes, Colin D., Nipp, Ryan D., Kwak, Eunice L., Allen, Jill N., Corcoran, Ryan B., Ting, David T., Faris, Jason E., Zhu, Andrew X., Goyal, Lipika, Berger, David L., Qadan, Motaz, Lillemoe, Keith D., Talele, Nilesh, Jain, Rakesh K., DeLaney, Thomas F., Duda, Dan G., Boucher, Yves, Fernández-Del Castillo, Carlos, Hong, Theodore S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2019
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547247/
https://ncbi.nlm.nih.gov/pubmed/31145418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2019.0892
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