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Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility

Modern genetic studies indicate that human brain evolution is driven primarily by changes in gene regulation, which requires understanding the biological function of largely non-coding gene regulatory elements, many of which act in tissue specific manner. We leverage chromatin interaction profiles i...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Won, Hyejung, Huang, Jerry, Opland, Carli K., Hartl, Chris L., Geschwind, Daniel H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546784/
https://ncbi.nlm.nih.gov/pubmed/31160561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10248-3
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