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Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility

Modern genetic studies indicate that human brain evolution is driven primarily by changes in gene regulation, which requires understanding the biological function of largely non-coding gene regulatory elements, many of which act in tissue specific manner. We leverage chromatin interaction profiles i...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Won, Hyejung, Huang, Jerry, Opland, Carli K., Hartl, Chris L., Geschwind, Daniel H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546784/
https://ncbi.nlm.nih.gov/pubmed/31160561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10248-3
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