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Structural basis for the clamping and Ca(2+) activation of SNARE-mediated fusion by synaptotagmin
Synapotagmin-1 (Syt1) interacts with both SNARE proteins and lipid membranes to synchronize neurotransmitter release to calcium (Ca(2+)) influx. Here we report the cryo-electron microscopy structure of the Syt1–SNARE complex on anionic-lipid containing membranes. Under resting conditions, the Syt1 C...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6546687/ https://ncbi.nlm.nih.gov/pubmed/31160571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10391-x |
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