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Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation
Preclinical studies demonstrate that rapid-acting antidepressants, including ketamine, require stimulation of mTORC1 signaling. This pathway is regulated by neuronal activity and endocrine and metabolic signals, notably including the amino acid leucine, which activates mTORC1 signaling via binding t...
שמור ב:
| הוצא לאור ב: | J Clin Invest |
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| Main Authors: | , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society for Clinical Investigation
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6546461/ https://ncbi.nlm.nih.gov/pubmed/30990795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126859 |
| תגים: |
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