Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation

Preclinical studies demonstrate that rapid-acting antidepressants, including ketamine, require stimulation of mTORC1 signaling. This pathway is regulated by neuronal activity and endocrine and metabolic signals, notably including the amino acid leucine, which activates mTORC1 signaling via binding t...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Kato, Taro, Pothula, Santosh, Liu, Rong-Jian, Duman, Catharine H., Terwilliger, Rosemarie, Vlasuk, George P., Saiah, Eddine, Hahm, Seung, Duman, Ronald S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546461/
https://ncbi.nlm.nih.gov/pubmed/30990795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126859
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