Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation

Preclinical studies demonstrate that rapid-acting antidepressants, including ketamine, require stimulation of mTORC1 signaling. This pathway is regulated by neuronal activity and endocrine and metabolic signals, notably including the amino acid leucine, which activates mTORC1 signaling via binding t...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:J Clin Invest
Glavni autori: Kato, Taro, Pothula, Santosh, Liu, Rong-Jian, Duman, Catharine H., Terwilliger, Rosemarie, Vlasuk, George P., Saiah, Eddine, Hahm, Seung, Duman, Ronald S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2019
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546461/
https://ncbi.nlm.nih.gov/pubmed/30990795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126859
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items