Scopolamine rapidly increases mTORC1 signaling, synaptogenesis, and antidepressant behavioral responses

BACKGROUND: Clinical studies report that scopolamine, an acetylcholine muscarinic receptor antagonist, produces rapid antidepressant effects in depressed patients, but the mechanisms underlying the therapeutic response have not been determined. The present study examines the role of the mammalian ta...

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Autori principali: Voleti, Bhavya, Navarria, Andrea, Liu, Rong-Jian, Banasr, Mounira, Li, Nanxin, Terwilliger, Rose, Sanacora, Gerard, Eid, Tore, Aghajanian, George, Duman, Ronald S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773272/
https://ncbi.nlm.nih.gov/pubmed/23751205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.04.025
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