Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin

Twenty-four hours after administration, ketamine exerts rapid and robust antidepressant effects that are thought to be mediated by activation of the mechanistic target of rapamycin complex 1 (mTORC1). To test this hypothesis, depressed patients were pretreated with rapamycin, an mTORC1 inhibitor, pr...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Abdallah, Chadi G., Averill, Lynnette A., Gueorguieva, Ralitza, Goktas, Selin, Purohit, Prerana, Ranganathan, Mohini, Sherif, Mohamed, Ahn, Kyung-Heup, D’Souza, Deepak Cyril, Formica, Richard, Southwick, Steven M., Duman, Ronald S., Sanacora, Gerard, Krystal, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162891/
https://ncbi.nlm.nih.gov/pubmed/32092760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-020-0644-9
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