Enhanced In Vivo Retention of Low Dose BMP-2 Via Heparin Microparticle Delivery Does Not Accelerate Bone Healing in a Critically Sized Femoral Defect

Bone morphogenetic protein-2 (BMP-2) is an osteoinductive growth factor used clinically to induce bone regeneration and fusion. Some complications associated with BMP-2 treatment have been attributed to rapid release of BMP-2 from conventional collagen scaffolds, motivating the development of tunabl...

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Bibliographic Details
Published in:Acta Biomater
Main Authors: Hettiaratchi, Marian H., Rouse, Tel, Chou, Catherine, Krishnan, Laxminarayanan, Stevens, Hazel Y., Li, Mon-Tzu A., McDevitt, Todd C., Guldberg, Robert E.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546418/
https://ncbi.nlm.nih.gov/pubmed/28645809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2017.06.028
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