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Delivery vehicle effects on bone regeneration and heterotopic ossification induced by high dose BMP-2

Bone morphogenetic protein-2 (BMP-2), delivered on absorbable collagen sponge, is frequently used to treat bone defects. However, supraphysiological BMP-2 doses are common and often associated with complications such as heterotopic ossification and inflammation, causing pain and impaired mobility. T...

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Vydáno v:Acta Biomater
Hlavní autoři: Krishnan, Laxminarayanan, Priddy, Lauren B, Esancy, Camden, Klosterhoff, Brett S, Stevens, Hazel Y, Tran, Lisa, Guldberg, Robert E
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5253230/
https://ncbi.nlm.nih.gov/pubmed/27940197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2016.12.012
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