Heparin-mediated delivery of bone morphogenetic protein-2 improves spatial localization of bone regeneration

Supraphysiologic doses of bone morphogenetic protein-2 (BMP-2) are used clinically to promote bone formation in fracture nonunions, large bone defects, and spinal fusion. However, abnormal bone formation (i.e., heterotopic ossification) caused by rapid BMP-2 release from conventional collagen sponge...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Hettiaratchi, Marian H., Krishnan, Laxminarayanan, Rouse, Tel, Chou, Catherine, McDevitt, Todd C., Guldberg, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941907/
https://ncbi.nlm.nih.gov/pubmed/31922007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay1240
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