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Hydrolysis and Sulfation Pattern Effects on Release of Bioactive Bone Morphogenetic Protein-2 from Heparin-Based Microparticles

Glycosaminoglycans (GAGs) such as heparin are promising materials for growth factor delivery due to their ability to efficiently bind positively charged growth factors including bone morphogenetic protein-2 (BMP-2) through their negatively charged sulfate groups. Therefore, the goal of this study wa...

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Pubblicato in:J Mater Chem B Mater Biol Med
Autori principali: Tellier, Liane E., Miller, Tobias, McDevitt, Todd C., Temenoff, Johnna S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077163/
https://ncbi.nlm.nih.gov/pubmed/27785363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C5TB00933B
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