Defining the seed sequence of the Cas12b CRISPR-Cas effector complex

Target binding by CRISPR-Cas ribonucleoprotein effectors is initiated by the recognition of double-stranded PAM motifs by the Cas protein moiety followed by destabilization, localized melting, and interrogation of the target by the guide part of CRISPR RNA moiety. The latter process depends on seed...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:RNA Biol
Egile Nagusiak: Jain, Ishita, Minakhin, Leonid, Mekler, Vladimir, Sitnik, Vasily, Rubanova, Natalia, Severinov, Konstantin, Semenova, Ekaterina
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2018
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546406/
https://ncbi.nlm.nih.gov/pubmed/30022698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2018.1495492
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