Defining the seed sequence of the Cas12b CRISPR-Cas effector complex

Target binding by CRISPR-Cas ribonucleoprotein effectors is initiated by the recognition of double-stranded PAM motifs by the Cas protein moiety followed by destabilization, localized melting, and interrogation of the target by the guide part of CRISPR RNA moiety. The latter process depends on seed...

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Vydáno v:RNA Biol
Hlavní autoři: Jain, Ishita, Minakhin, Leonid, Mekler, Vladimir, Sitnik, Vasily, Rubanova, Natalia, Severinov, Konstantin, Semenova, Ekaterina
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546406/
https://ncbi.nlm.nih.gov/pubmed/30022698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2018.1495492
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