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RNA sequencing of isolated cell populations expressing human APOL1 G2 risk variant reveals molecular correlates of sickle cell nephropathy in zebrafish podocytes

Kidney failure occurs in 5–13% of individuals with sickle cell disease and is associated with early mortality. Two APOL1 alleles (G1 and G2) have been identified as risk factors for sickle cell disease nephropathy. Both risk alleles are prevalent in individuals with recent African ancestry and have...

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Pubblicato in:PLoS One
Autori principali: Bundy, Joseph L., Anderson, Blair R., Francescatto, Ludmila, Garrett, Melanie E., Soldano, Karen L., Telen, Marilyn J., Davis, Erica E., Ashley-Koch, Allison E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546218/
https://ncbi.nlm.nih.gov/pubmed/31158233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217042
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