In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress

African Americans have a disproportionate risk for developing nephropathy. This disparity has been attributed to coding variants (G1 and G2) in apolipoprotein L1 (APOL1); however, there is little functional evidence supporting the role of this protein in renal function. Here, we combined genetics an...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Anderson, Blair R., Howell, David N., Soldano, Karen, Garrett, Melanie E., Katsanis, Nicholas, Telen, Marilyn J., Davis, Erica E., Ashley-Koch, Allison E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492502/
https://ncbi.nlm.nih.gov/pubmed/26147622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005349
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