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RNA sequencing of isolated cell populations expressing human APOL1 G2 risk variant reveals molecular correlates of sickle cell nephropathy in zebrafish podocytes

Kidney failure occurs in 5–13% of individuals with sickle cell disease and is associated with early mortality. Two APOL1 alleles (G1 and G2) have been identified as risk factors for sickle cell disease nephropathy. Both risk alleles are prevalent in individuals with recent African ancestry and have...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Bundy, Joseph L., Anderson, Blair R., Francescatto, Ludmila, Garrett, Melanie E., Soldano, Karen L., Telen, Marilyn J., Davis, Erica E., Ashley-Koch, Allison E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546218/
https://ncbi.nlm.nih.gov/pubmed/31158233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217042
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