WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks

DNA double-strand breaks (DSBs) at RNA polymerase II (RNAPII) transcribed genes lead to inhibition of transcription. The DNA-dependent protein kinase (DNA-PK) complex plays a pivotal role in transcription inhibition at DSBs by stimulating proteasome-dependent eviction of RNAPII at these lesions. How...

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Détails bibliographiques
Publié dans:Genes Dev
Auteurs principaux: Caron, Pierre, Pankotai, Tibor, Wiegant, Wouter W., Tollenaere, Maxim A.X., Furst, Audrey, Bonhomme, Celine, Helfricht, Angela, de Groot, Anton, Pastink, Albert, Vertegaal, Alfred C.O., Luijsterburg, Martijn S., Soutoglou, Evi, van Attikum, Haico
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2019
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546063/
https://ncbi.nlm.nih.gov/pubmed/31048545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.321943.118
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