Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery

BACKGROUND: The blood brain barrier (BBB) is the bottleneck of brain-targeted drug development. Due to their physico-chemical properties, nanoparticles (NP) can cross the BBB and accumulate in different areas of the central nervous system (CNS), thus are potential tools to carry drugs and treat brai...

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Detalhes bibliográficos
Publicado no:Part Fibre Toxicol
Main Authors: Leite, Paulo Emílio Corrêa, Pereira, Mariana Rodrigues, Harris, Georgina, Pamies, David, dos Santos, Lisia Maria Gobbo, Granjeiro, José Mauro, Hogberg, Helena T., Hartung, Thomas, Smirnova, Lena
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6545685/
https://ncbi.nlm.nih.gov/pubmed/31159811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12989-019-0307-3
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