Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription

The C-terminal domain (CTD) of RNA polymerase II contains a repetitive heptad sequence (YSPTSPS) whose phosphorylation states coordinate eukaryotic transcription by recruiting protein regulators. The precise placement and removal of phosphate groups on specific residues of the CTD are critical for t...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Irani, Seema, Sipe, Sarah N., Yang, Wanjie, Burkholder, Nathaniel T., Lin, Brian, Sim, Kelly, Matthews, Wendy L., Brodbelt, Jennifer S., Zhang, Yan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544836/
https://ncbi.nlm.nih.gov/pubmed/30971428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007697
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