Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb

The Positive Transcription Elongation Factor b (P-TEFb) phosphorylates Ser2 residues of the C-terminal domain (CTD) of the largest subunit (RPB1) of RNA polymerase II and is essential for the transition from transcription initiation to elongation in vivo. Surprisingly, P-TEFb exhibits Ser5 phosphory...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Mayfield, Joshua E, Irani, Seema, Escobar, Edwin E, Zhang, Zhao, Burkholder, Nathaniel T, Robinson, Michelle R, Mehaffey, M Rachel, Sipe, Sarah N, Yang, Wanjie, Prescott, Nicholas A, Kathuria, Karan R, Liu, Zhijie, Brodbelt, Jennifer S, Zhang, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715403/
https://ncbi.nlm.nih.gov/pubmed/31385803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48725
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