Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription

The C-terminal domain (CTD) of RNA polymerase II contains a repetitive heptad sequence (YSPTSPS) whose phosphorylation states coordinate eukaryotic transcription by recruiting protein regulators. The precise placement and removal of phosphate groups on specific residues of the CTD are critical for t...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Irani, Seema, Sipe, Sarah N., Yang, Wanjie, Burkholder, Nathaniel T., Lin, Brian, Sim, Kelly, Matthews, Wendy L., Brodbelt, Jennifer S., Zhang, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544836/
https://ncbi.nlm.nih.gov/pubmed/30971428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007697
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