Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription

The C-terminal domain (CTD) of RNA polymerase II contains a repetitive heptad sequence (YSPTSPS) whose phosphorylation states coordinate eukaryotic transcription by recruiting protein regulators. The precise placement and removal of phosphate groups on specific residues of the CTD are critical for t...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Irani, Seema, Sipe, Sarah N., Yang, Wanjie, Burkholder, Nathaniel T., Lin, Brian, Sim, Kelly, Matthews, Wendy L., Brodbelt, Jennifer S., Zhang, Yan
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2019
Sujets:
Protein Structure and Folding
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544836/
https://ncbi.nlm.nih.gov/pubmed/30971428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007697
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