Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription

The C-terminal domain (CTD) of RNA polymerase II contains a repetitive heptad sequence (YSPTSPS) whose phosphorylation states coordinate eukaryotic transcription by recruiting protein regulators. The precise placement and removal of phosphate groups on specific residues of the CTD are critical for t...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Irani, Seema, Sipe, Sarah N., Yang, Wanjie, Burkholder, Nathaniel T., Lin, Brian, Sim, Kelly, Matthews, Wendy L., Brodbelt, Jennifer S., Zhang, Yan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544836/
https://ncbi.nlm.nih.gov/pubmed/30971428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007697
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