Dysregulation of the SNARE-binding protein Munc18-1 impairs BDNF secretion and synaptic neurotransmission: a novel interventional target to protect the aging brain

Brain-derived neurotrophic factor (BDNF) has a central role in maintaining and strengthening neuronal connections and to stimulate neurogenesis in the adult brain. Decreased levels of BDNF in the aging brain are thought to usher cognitive impairment. BDNF is stored in dense core vesicles and release...

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Publicat a:GeroScience
Autors principals: Lee, Young Il, Kim, Yun Gi, Pyeon, Hee Jang, Ahn, Jin Chul, Logan, Sreemathi, Orock, Albert, Joo, Kyeung Min, Lőrincz, Andrea, Deák, Ferenc
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2019
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544690/
https://ncbi.nlm.nih.gov/pubmed/31041658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-019-00067-1
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