Dysregulation of the SNARE-binding protein Munc18-1 impairs BDNF secretion and synaptic neurotransmission: a novel interventional target to protect the aging brain

Brain-derived neurotrophic factor (BDNF) has a central role in maintaining and strengthening neuronal connections and to stimulate neurogenesis in the adult brain. Decreased levels of BDNF in the aging brain are thought to usher cognitive impairment. BDNF is stored in dense core vesicles and release...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:GeroScience
Main Authors: Lee, Young Il, Kim, Yun Gi, Pyeon, Hee Jang, Ahn, Jin Chul, Logan, Sreemathi, Orock, Albert, Joo, Kyeung Min, Lőrincz, Andrea, Deák, Ferenc
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2019
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544690/
https://ncbi.nlm.nih.gov/pubmed/31041658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-019-00067-1
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker