Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming

Munc18-1 and soluble NSF attachment protein receptors (SNAREs) are critical for synaptic vesicle fusion. Munc18-1 binds to the SNARE syntaxin-1 folded into a closed conformation and to SNARE complexes containing open syntaxin-1. Understanding which steps in fusion depend on the latter interaction an...

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Autors principals: Deák, Ferenc, Xu, Yi, Chang, Wen-Pin, Dulubova, Irina, Khvotchev, Mikhail, Liu, Xinran, Südhof, Thomas C., Rizo, Josep
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2009
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686405/
https://ncbi.nlm.nih.gov/pubmed/19255244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200812026
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