Dysregulation of the SNARE-binding protein Munc18-1 impairs BDNF secretion and synaptic neurotransmission: a novel interventional target to protect the aging brain

Brain-derived neurotrophic factor (BDNF) has a central role in maintaining and strengthening neuronal connections and to stimulate neurogenesis in the adult brain. Decreased levels of BDNF in the aging brain are thought to usher cognitive impairment. BDNF is stored in dense core vesicles and release...

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Dettagli Bibliografici
Pubblicato in:GeroScience
Autori principali: Lee, Young Il, Kim, Yun Gi, Pyeon, Hee Jang, Ahn, Jin Chul, Logan, Sreemathi, Orock, Albert, Joo, Kyeung Min, Lőrincz, Andrea, Deák, Ferenc
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2019
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544690/
https://ncbi.nlm.nih.gov/pubmed/31041658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-019-00067-1
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