Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration

BACKGROUND AND OBJECTIVES: Inhibition of Abelson (Abl) tyrosine kinase as a therapeutic target has been gaining attention in neurodegeneration. Post-mortem Alzheimer’s and Parkinson’s disease brains show that the levels of several other tyrosine kinases, including Discoidin Domain Receptors (DDR1/2)...

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Enregistré dans:
Détails bibliographiques
Publié dans:Drugs R D
Auteurs principaux: Fowler, Alan J., Hebron, Michaeline, Missner, Alexander A., Wang, Ruchong, Gao, Xiaokong, Kurd-Misto, Bahjat T., Liu, Xiaoguang, Moussa, Charbel E.-H.
Format: Artigo
Langue:Inglês
Publié: Springer International Publishing 2019
Sujets:
Original Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544596/
https://ncbi.nlm.nih.gov/pubmed/30919310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40268-019-0266-z
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