Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+

Imaging the transcriptome in situ with high accuracy has been a major challenge in single cell biology, particularly hindered by the limits of optical resolution and the density of transcripts in single cells(1–5). Here, we demonstrate seqFISH+, that can image the mRNAs for 10,000 genes in single ce...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Eng, Chee-Huat Linus, Lawson, Michael, Zhu, Qian, Dries, Ruben, Koulena, Noushin, Takei, Yodai, Yun, Jina, Cronin, Christopher, Karp, Christoph, Yuan, Guo-Cheng, Cai, Long
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544023/
https://ncbi.nlm.nih.gov/pubmed/30911168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1049-y
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