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Increased acetylation of H3K14 in the genomic regions that encode trained immunity enzymes in lysophosphatidylcholine-activated human aortic endothelial cells – Novel qualification markers for chronic disease risk factors and conditional DAMPs

To test our hypothesis that proatherogenic lysophosphatidylcholine (LPC) upregulates trained immunity pathways (TIPs) in human aortic endothelial cells (HAECs), we conducted an intensive analyses on our RNA-Seq data and histone 3 lysine 14 acetylation (H3K14ac)-CHIP-Seq data, both performed on HAEC...

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書誌詳細
出版年:Redox Biol
主要な著者: Lu, Yifan, Sun, Yu, Drummer, Charles, Nanayakkara, Gayani K., Shao, Ying, Saaoud, Fatma, Johnson, Candice, Zhang, Ruijing, Yu, Daohai, Li, Xinyuan, Yang, William Y., Yu, Jun, Jiang, Xiaohua, Choi, Eric T., Wang, Hong, Yang, Xiaofeng
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6543097/
https://ncbi.nlm.nih.gov/pubmed/31153039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101221
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