Increased acetylation of H3K14 in the genomic regions that encode trained immunity enzymes in lysophosphatidylcholine-activated human aortic endothelial cells – Novel qualification markers for chronic disease risk factors and conditional DAMPs

To test our hypothesis that proatherogenic lysophosphatidylcholine (LPC) upregulates trained immunity pathways (TIPs) in human aortic endothelial cells (HAECs), we conducted an intensive analyses on our RNA-Seq data and histone 3 lysine 14 acetylation (H3K14ac)-CHIP-Seq data, both performed on HAEC...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Lu, Yifan, Sun, Yu, Drummer, Charles, Nanayakkara, Gayani K., Shao, Ying, Saaoud, Fatma, Johnson, Candice, Zhang, Ruijing, Yu, Daohai, Li, Xinyuan, Yang, William Y., Yu, Jun, Jiang, Xiaohua, Choi, Eric T., Wang, Hong, Yang, Xiaofeng
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6543097/
https://ncbi.nlm.nih.gov/pubmed/31153039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101221
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