Increased acetylation of H3K14 in the genomic regions that encode trained immunity enzymes in lysophosphatidylcholine-activated human aortic endothelial cells – Novel qualification markers for chronic disease risk factors and conditional DAMPs

To test our hypothesis that proatherogenic lysophosphatidylcholine (LPC) upregulates trained immunity pathways (TIPs) in human aortic endothelial cells (HAECs), we conducted an intensive analyses on our RNA-Seq data and histone 3 lysine 14 acetylation (H3K14ac)-CHIP-Seq data, both performed on HAEC...

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Veröffentlicht in:Redox Biol
Hauptverfasser: Lu, Yifan, Sun, Yu, Drummer, Charles, Nanayakkara, Gayani K., Shao, Ying, Saaoud, Fatma, Johnson, Candice, Zhang, Ruijing, Yu, Daohai, Li, Xinyuan, Yang, William Y., Yu, Jun, Jiang, Xiaohua, Choi, Eric T., Wang, Hong, Yang, Xiaofeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6543097/
https://ncbi.nlm.nih.gov/pubmed/31153039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101221
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