The target landscape of clinical kinase drugs

Kinase inhibitors are important cancer therapeutics; 37 such drugs are approved for human use and >250 are undergoing clinical trials. Polypharmacology is commonly observed requiring thorough target deconvolution to understand drug mechanism-of-action. Using a dose-resolved quantitative chemical...

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מידע ביבליוגרפי
הוצא לאור ב:Science
Main Authors: Klaeger, Susan, Heinzlmeir, Stephanie, Wilhelm, Mathias, Polzer, Harald, Vick, Binje, Koenig, Paul-Albert, Reinecke, Maria, Ruprecht, Benjamin, Petzoldt, Svenja, Meng, Chen, Zecha, Jana, Reiter, Katrin, Qiao, Huichao, Helm, Dominic, Koch, Heiner, Schoof, Melanie, Canevari, Giulia, Casale, Elena, Re Depaolini, Stefania, Feuchtinger, Annette, Wu, Zhixiang, Schmidt, Tobias, Rueckert, Lars, Becker, Wilhelm, Huenges, Jan, Garz, Anne-Kathrin, Gohlke, Bjoern-Oliver, Zolg, Daniel Paul, Kayser, Gian, Vooder, Tonu, Preissner, Robert, Hahne, Hannes, Tonisson, Neeme, Kramer, Karl, Goetze, Katharina, Bassermann, Florian, Schlegl, Judith, Ehrlich, Hans-Christian, Aiche, Stephan, Walch, Axel, Greif, Philipp A., Schneider, Sabine, Felder, Eduard Rudolf, Ruland, Juergen, Medard, Guillaume, Jeremias, Irmela, Spiekermann, Karsten, Kuster, Bernhard
פורמט: Artigo
שפה:Inglês
יצא לאור: 2017
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542668/
https://ncbi.nlm.nih.gov/pubmed/29191878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan4368
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