Dysfunctional peripheral T follicular helper cells dominate in people with impaired influenza vaccine responses: Results from the FLORAH study

Antigen-primed cluster of differentiation (CD) 4(+) T follicular helper (Tfh) cells interact with B cells in the germinal centers (GCs) of lymph nodes to generate vaccine-induced antibody (Ab) responses. In the circulation, peripheral Tfh (pTfh) cells, a subset of memory CD4 T cells, serve as surrog...

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Udgivet i:PLoS Biol
Main Authors: Pallikkuth, Suresh, de Armas, Lesley R., Rinaldi, Stefano, George, Varghese K., Pan, Li, Arheart, Kristopher L., Pahwa, Rajendra, Pahwa, Savita
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542545/
https://ncbi.nlm.nih.gov/pubmed/31100059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000257
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