Arrestin-β-1 Physically Scaffolds TSH and IGF1 Receptors to Enable Crosstalk

Endogenously expressed TSH receptors (TSHRs) on orbital fibroblasts of patients with Graves ophthalmopathy (GO) use crosstalk with IGF1 receptors (IGF1R) to synergistically stimulate secretion of hyaluronan (HA), a major component of GO pathology. We previously showed crosstalk occurred upstream of...

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Publicat a:Endocrinology
Autors principals: Krieger, Christine C, Boutin, Alisa, Jang, Daesong, Morgan, Sarah J, Banga, J Paul, Kahaly, George J, Klubo-Gwiezdzinska, Joanna, Neumann, Susanne, Gershengorn, Marvin C
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2019
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542485/
https://ncbi.nlm.nih.gov/pubmed/31127272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2019-00055
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