The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals Using High-throughput Transcriptomics and Benchmark Concentration Modeling

Prediction of human response to chemical exposures is a major challenge in both pharmaceutical and toxicological research. Transcriptomics has been a powerful tool to explore chemical-biological interactions, however, limited throughput, high-costs, and complexity of transcriptomic interpretations h...

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Dades bibliogràfiques
Publicat a:Toxicol Sci
Autors principals: Ramaiahgari, Sreenivasa C, Auerbach, Scott S, Saddler, Trey O, Rice, Julie R, Dunlap, Paul E, Sipes, Nisha S, DeVito, Michael J, Shah, Ruchir R, Bushel, Pierre R, Merrick, Bruce A, Paules, Richard S, Ferguson, Stephen S
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
High-Throughput Transcriptomics and Chemical-Induced Liver Injury
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542332/
https://ncbi.nlm.nih.gov/pubmed/30850835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz065
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