Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes

A 5-day in vivo rat model was evaluated as an approach to estimate chemical exposures that may pose minimal risk by comparing benchmark dose (BMD) values for transcriptional changes in the liver and kidney to BMD values for toxicological endpoints from traditional toxicity studies. Eighteen chemical...

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Publicado en:Toxicol Sci
Autores principales: Gwinn, William M, Auerbach, Scott S, Parham, Fred, Stout, Matthew D, Waidyanatha, Suramya, Mutlu, Esra, Collins, Brad, Paules, Richard S, Merrick, Bruce Alex, Ferguson, Stephen, Ramaiahgari, Sreenivasa, Bucher, John R, Sparrow, Barney, Toy, Heather, Gorospe, Jenni, Machesky, Nick, Shah, Ruchir R, Balik-Meisner, Michele R, Mav, Deepak, Phadke, Dhiral P, Roberts, Georgia, DeVito, Michael J
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Emerging Technologies, Methods, and Models
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7416315/
https://ncbi.nlm.nih.gov/pubmed/32492150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa081
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