Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes

A 5-day in vivo rat model was evaluated as an approach to estimate chemical exposures that may pose minimal risk by comparing benchmark dose (BMD) values for transcriptional changes in the liver and kidney to BMD values for toxicological endpoints from traditional toxicity studies. Eighteen chemical...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Gwinn, William M, Auerbach, Scott S, Parham, Fred, Stout, Matthew D, Waidyanatha, Suramya, Mutlu, Esra, Collins, Brad, Paules, Richard S, Merrick, Bruce Alex, Ferguson, Stephen, Ramaiahgari, Sreenivasa, Bucher, John R, Sparrow, Barney, Toy, Heather, Gorospe, Jenni, Machesky, Nick, Shah, Ruchir R, Balik-Meisner, Michele R, Mav, Deepak, Phadke, Dhiral P, Roberts, Georgia, DeVito, Michael J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Emerging Technologies, Methods, and Models
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7416315/
https://ncbi.nlm.nih.gov/pubmed/32492150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa081
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