Bispecific NKG2D-CD3 and NKG2D-CD16 fusion proteins for induction of NK and T cell reactivity against acute myeloid leukemia

BACKGROUND: Monoclonal antibodies (mAbs) mediate their effects in great part by inducing ADCC of NK cells, and multiple efforts aim to increase this function by engineering mAbs optimized Fc-parts. Even more potent antitumor immunity can be induced by strategies to stimulate T cells with their profo...

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Vydáno v:J Immunother Cancer
Hlavní autoři: Märklin, Melanie, Hagelstein, Ilona, Koerner, Samuel P., Rothfelder, Kathrin, Pfluegler, Martin S., Schumacher, Andreas, Grosse-Hovest, Ludger, Jung, Gundram, Salih, Helmut R.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542021/
https://ncbi.nlm.nih.gov/pubmed/31142382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0606-0
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