Characterization of a Bispecific FLT3 X CD3 Antibody in an Improved, Recombinant Format for the Treatment of Leukemia

FLT3 is a receptor-tyrosine-kinase that is expressed on leukemic cells of the myeloid and lymphoid lineage rather specifically. We here report on the construction and selection of bispecific FLT3 X CD3 antibodies in a new recombinant format, termed Fabsc, that resembles the normal antibody structure...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Durben, Michael, Schmiedel, Dominik, Hofmann, Martin, Vogt, Fabian, Nübling, Tina, Pyz, Elwira, Bühring, Hans-Jörg, Rammensee, Hans-Georg, Salih, Helmut R, Große-Hovest, Ludger, Jung, Gundram
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395786/
https://ncbi.nlm.nih.gov/pubmed/25578618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.2
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