Bispecific NKG2D-CD3 and NKG2D-CD16 Fusion Proteins as Novel Treatment Option in Advanced Soft Tissue Sarcomas

Soft tissue sarcoma (STS) constitutes a rare group of heterogeneous malignancies. Effective treatment options for most subtypes of STS are still limited. As a result, especially in metastatic disease, prognosis is still dismal. The ligands for the activating immunoreceptor NKG2D (NKG2DL) are commonl...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Hagelstein, Ilona, Lutz, Martina S., Schmidt, Moritz, Heitmann, Jonas S., Malenke, Elke, Zhou, Yanjun, Clar, Kim L., Kopp, Hans-Georg, Jung, Gundram, Salih, Helmut R., Märklin, Melanie, Hinterleitner, Clemens
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079770/
https://ncbi.nlm.nih.gov/pubmed/33936075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.653081
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