Targeted antibody and cytokine cancer immunotherapies through collagen affinity

Cancer immunotherapy with immune checkpoint inhibitors (CPI) and interleukin (IL)-2 has demonstrated clinical efficacy but is frequently accompanied with severe adverse events caused by excessive and systemic immune system activation. Here, we addressed this need by targeting both the CPI antibodies...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Ishihara, Jun, Ishihara, Ako, Sasaki, Koichi, Lee, Steve Seung-Young, Williford, John-Michael, Yasui, Mariko, Abe, Hiroyuki, Potin, Lambert, Hosseinchi, Peyman, Fukunaga, Kazuto, Raczy, Michal M., Gray, Laura T., Mansurov, Aslan, Katsumata, Kiyomitsu, Fukayama, Masashi, Kron, Stephen J., Swartz, Melody A., Hubbell, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6541444/
https://ncbi.nlm.nih.gov/pubmed/30971453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aau3259
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