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Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing

Laminin, as a key component of the basement membrane extracellular matrix (ECM), regulates tissue morphogenesis. Here, we show that multiple laminin isoforms promiscuously bind to growth factors (GFs) with high affinity, through their heparin-binding domains (HBDs) located in the α chain laminin-typ...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Ishihara, Jun, Ishihara, Ako, Fukunaga, Kazuto, Sasaki, Koichi, White, Michael J. V., Briquez, Priscilla S., Hubbell, Jeffrey A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986797/
https://ncbi.nlm.nih.gov/pubmed/29867149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04525-w
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