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Targeting inflammatory sites through collagen affinity enhances the therapeutic efficacy of anti-inflammatory antibodies

Enhancing the therapeutic efficacy of drugs for inflammatory diseases is of high demand. One possible approach is targeting drugs to the extracellular matrix of the inflamed area. Here, we target collagens in the matrix, which are inaccessible in most tissues yet are exposed to the bloodstream in th...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Katsumata, Kiyomitsu, Ishihara, Jun, Mansurov, Aslan, Ishihara, Ako, Raczy, Michal M., Yuba, Eiji, Hubbell, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6834392/
https://ncbi.nlm.nih.gov/pubmed/31723606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay1971
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