ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine

BACKGROUND: Triple-negative breast cancer (TNBC) is often aggressive and associated with a poor prognosis. Due to the lack of available targeted therapies and to problems of resistance with conventional chemotherapeutic agents, finding new treatments for TNBC remains a challenge and a better therape...

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Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: Hu, Jinjiao, Zhang, Yanhao, Jiang, Xiuxing, Zhang, Hongwei, Gao, Ziyi, Li, Yunong, Fu, Ruoqiu, Li, Lirong, Li, Jie, Cui, Hongjuan, Gao, Ning
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540563/
https://ncbi.nlm.nih.gov/pubmed/31138329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1201-4
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